How is the resistance in Carbapenem Resistant Enterobacteriaceae primarily mediated?

Study for the Antimicrobial Stewardship Test. Study with flashcards and multiple-choice questions, each with explanations and hints. Prepare for your exam!

Carbapenem-resistant Enterobacteriaceae (CRE) primarily acquire resistance through plasmid-mediated genes. This is significant because plasmids are small, circular DNA molecules that can be easily transferred between bacteria, facilitating the rapid spread of resistance traits among different bacterial species.

Plasmids often carry genes encoding beta-lactamase enzymes, such as KPC (Klebsiella pneumoniae carbapenemase), which break down carbapenems and other beta-lactam antibiotics. The ability of these plasmids to replicate independently of chromosomal DNA allows for the wide dissemination of resistance mechanisms in various environments, contributing to the global challenge of antibiotic resistance.

While chromosomal alterations and transposon elements can play roles in bacterial resistance, the primary and most concerning mechanism in CRE cases is indeed the presence and transfer of plasmid-mediated genes. Virus incorporation does not apply to the mechanism of antibiotic resistance in CRE, as phages (viruses that infect bacteria) typically do not confer antibiotic resistance in this context.

Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy